Do Interictal Spikes Sustain Seizures and Epileptogenesis?
نویسندگان
چکیده
منابع مشابه
Do interictal spikes sustain seizures and epileptogenesis?
Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, the roles played by interictal events in seizure occurrence and in epileptogenesis remain elusive. While interictal spikes may herald the onset of electrographic seizures, experimental data indicate that hippocampus-driven interictal events prevent seizure precipitation. Even less clear than the role of inter...
متن کاملSeizures, Epileptogenesis, and Epilepsy
ber of diverse variables. Some of these factors, such as genes that influence seizure susceptibility, are internal. Others, which alter normal brain excitability, such as traumatic brain injury, are external. As described elsewhere in this volume, these variables can AQ? Specific cross-ref to chapter number? have different and distinct effects. For example, genes may influence both the developm...
متن کاملPredictability of EEG interictal spikes.
To determine whether EEG spikes are predictable, time series of EEG spike intervals were generated from subdural and depth electrode recordings from four patients. The intervals between EEG spikes were hand edited to ensure high accuracy and eliminate false positive and negative spikes. Spike rates (per minute) were generated from longer time series, but for these data hand editing was usually ...
متن کاملInterictal epileptiform discharges do not change before seizures during sleep.
PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...
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The mechanisms that control the periodicity of spontaneous epileptiform cortical potentials were investigated in the in vitro isolated guinea pig brain preparation. A brief intracortical application of bicuculline in the piriform cortex induced spontaneous interictal spikes (sISs) that recurred with high periodicity (8.5 +/- 3.1 sec, mean +/- SD). Intracellular recordings from principal neurons...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2006
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7511.2006.00146.x